Featuring Nagarjuna, Karthi in the lead roles, the film is said to be an adaptation of French film The Intouchables. Though initially the film was supposed to have NTR, later Karthi joined in his place. Talking about it, Vamshi says, "In fact, I should thank NTR. It's him who called Nagarjuna sir and told him that I'm coming up with an experimental story and requested him to not to scold me. And Nag sir always open to the idea of experiments and he immensely liked the adapted script and gave us full support. So, it's NTR who laid foundation stone for Oopiri. I should thank him."
Sharing a heart-touching story he encountered with during the making of Oopiri, Vamshi narrates, "When we went for a recce near Eiffel tower, a woman came to us and asked whether we're remaking The Intouchables and when I nodded, she was visibly touched and shook my hands. She has pointed her son who's at a long distance sitting in a wheel chair and told us how he met with an accident and turned a paraplegic. As per her, her son had wanted to commit suicide but dropped his plans after watching The Intouchables. She told us how inspiring film it is and asked us to use her restaurant and willing to give her complete support for shooting the film there. This gave us big strength and belief even before we shoot the film in Paris."
Like many others, Vamshi initially wanted to have an Indianised version of Intouchables and made script such that there's a flashback to protagonist Nagarjuna. "But Nag sir asked me not to deviate the story for him. He asked me to keep the soul as it is. So, we took two more months and reworked the film's second half for 2 more months. That's how Oopiri is made." Vamshi reiterates Nag's words that Oopiri is "life-changing film" for all.